MDV 3100
货号：
11596-50mg 基本售价：
9996.0 元 规格：
50 mg
产品信息
概述| 货号 | 11596-50mg |
| 描述 | MDV 3100 is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).1,2 It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.1 It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.1 It has applications in advanced cancers that remain dependent on androgen receptor signaling even in the absence of androgen.3 |
| 别名 | Enzalutamide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tran, C.,Ouk, S.,Clegg, N.J., et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324(5928), 787-790 (2009).
2.Jung, M.E.,Ouk, S.,Yoo, D., et al. Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC). Journal of Medicinal Chemistry 53(7), 2779-2796 (2010).
3.Semenas, J.,Dizeyi, N., and Persson, J.L. Enzalutamide as a second generation antiandrogen for treatment of advanced prostate cancer. Drug Des.Devel.Ther. 7, 875-881 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464.4 |
| 分子式 | C21H16F4N4O2S |
| CAS号 | 915087-33-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
