| 货号 | 12079-5mg |
| 描述 | Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.1,2 In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes.3 1,24-dihydroxy Vitamin D3 is an analog of 1,25-dihydroxy vitamin D3 which, when used in a 4 μg/g ointment, safely and effectively suppresses psoriasis.4 It also is effective at increasing the time interval between phototherapy cycles when ultraviolet light is used for psoriasis.5 1,24-dihydroxy Vitamin D3 inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor.6 It also suppresses the production of RANTES and IL-8 by human dermal fibroblasts and reduces cutaneous lymphocyte-associated antigen on CD4+ T cells, impairing migration and skin infiltration.7,8 |
| 别名 | Bonalfa;Curatoderm;1α,24(R)-Dihydroxycholecalciferol;PRI 2191;Tacalcitol;TV 02; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Holick, M.F. Vitamin D deficiency. New England Journal of Medicine 357(3), 266-281 (2007). 2.Peterlik, M.,Boonen, S.,Cross, H.S., et al. Vitamin D and calcium insufficiency-related chronic diseases: An emerging world-wide public health problem. Int.J.Environ.Res.Public Health 6, 2585-2607 (2009). 3.Bikle, D.D. 1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: Basic studies and their clinical application. Journal of Nutrition 125, 1709S-1714S (1995). 4.Leone, G., and Pacifico, A. Profile of clinical efficacy and safety of topical tacalcitol. Acta.Biomed. 76, 13-19 (2005). 5.Prignano, F.,Buggiani, G., and Lotti, T. Clinical evaluation of topical tacalcitol efficacy in extending the remission period between nb-UVB phototherapy cycles in psoriatic patients. Acta.Biomed. 80, 51-56 (2009). 6.Matsumoto, K.,Hashimoto, K.,Kiyoki, M., et al. Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes. J.Dermatol. 17, 97-103 (1990). 7.Fukuoka, M.,Ogino, Y.,Sato, H., et al. Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol). British Journal of Pharmacology 124(7), 1433-1438 (1998). 8.Yamanaka, K.I.,Kakeda, M.,Kitagawa, H., et al. 1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration. British Journal of Dermatology 162(6), 1206-1215 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.6 |
| 分子式 | C27H44O3 |
| CAS号 | 57333-96-7 |
| 稳定性 | ≥ 2 years |
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