Paliperidone
货号：
15556-500mg 基本售价：
9912.0 元 规格：
500 mg
产品信息
概述| 货号 | 15556-500mg |
| 描述 | Paliperidone is a potent antagonist of dopamine receptors (IC50s = 1.0 and 0.9 nM for D2 and D3, respectively).1 It also avidly binds α1- and α2-adrenergic receptors, histamine H1 receptor, and serotonin (5-HT) receptors 5-HT1D and 5-HT2A(Kis = 10, 80, 3.4, 19, 1.2 nM, respectively).2 Paliperidone is also known as 9-hydroxy risperidone and is the major metabolite of the antipsychotic medication risperidone (Item No. 13629).3 |
| 别名 | 9-hydroxy Risperidone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Burstein, E.S.,Ma, J.,Wong, S., et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. Journal of Pharmacology and Experimental Therapeutics 315(3), 1278-1287 (2005).
2.Richelson, E. and Souder, T. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sciences 68(1), 29-39 (2000).
3.Citrome, L. Paliperidone palmitate - review of the efficacy, safety and cost of a new second-generation depot antipsychotic medication. International Journal of Clinical Practice 64(2), 216-239 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 426.5 |
| 分子式 | C23H27FN4O3 |
| CAS号 | 144598-75-4 |
| 稳定性 | ≥ 2 years |
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