VU 0364770 (50 MG)
货号：
4469/50 基本售价：
9894.7 元 规格：
50 mg
产品信息
概述| 货号 | 4469/50 |
| 别名 | N-(3-Chlorophenyl)-2-pyridinecarboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 232.67 |
| 分子式 | C12H9ClN2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Joneset al (2012) The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinsons disease. J.Pharmacol.Exp.Ther. 340 404. PMID: 22088953. |
