| 货号 | 4206/50 |
| 别名 | 4-(5-Methyl-3-phenylisoxazol-4-yl)b |
| 供应商 | Tocris |
| 生物活性 | Selective and potent COX-2 inhibitor (in vitroIC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 314.36 |
| 分子式 | C16H14N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Gierseet al (2005) Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 312 1206. PMID: 15494548. Walkeret al (2001) A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 357 709. PMID: 11463341. Talleyet al (2000) 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 43 775. PMID: 10715145. |