| 货号 | 2892/50 |
| 别名 | (1S*,2S*)-threo-2-(4-Benzylpiperidi |
| 供应商 | Tocris |
| 生物活性 | Potentσ receptor agonist (Ki values are 59.1 and 2 nM for σ1 and σ2 receptors respectively) and NR2B subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 μM at NR2B and NR2A respectively). Displays ~8-fold reduced affinity at α-adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 400.49 |
| 分子式 | C21H27NO2.紺4H6O6 |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 74991-34-7 |
| 参考文献 | Monassieret al (2007) σ2-receptor ligand-mediated inhibition of inwardly rectifying K+channels in the heart. J.Pharmacol.Exp.Ther. 322 341. PMID: 17460149. Avenetet al (1996) Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes. Eur.J.Pharmacol. 296 209. PMID: 8838458. Hashimoto and London (1995) Interactions of erythro-ifenprodil,threo-ifenprodil and erythro-iodoifenprodil, and eliprodil with subtypes of σ receptors. Eur.J.Pharmacol. 273 307. PMID: 7737340. |