| 货号 | 3818/50 |
| 别名 | N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-meth |
| 供应商 | Tocris |
| 生物活性 | Potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 470.59 |
| 分子式 | C27H26N4O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 916141-36-1 |
| 参考文献 | Winrowet al (2010) Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology 58 185. PMID: 19596018. Bergmanet al (2008) Proline bis-amides as potent dual orexin receptor antagonists. Bioorg.Med.Chem.Letts 181425. |