| 货号 | 3866/50 |
| 别名 | 6-Chloro-N-methyl-2,3,4,5-tetrahydr |
| 供应商 | Tocris |
| 生物活性 | Potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 232.15 |
| 分子式 | C11H14ClN.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Schaferset al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884. PMID: 1981137. Roesleret al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1. PMID: 2867209. Hiebleet al (1985) Selective Alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 23690. |