| 货号 | 4189/50 |
| 别名 | α,α-Diphenyl-4-[(3-pyridinylmethylene |
| 供应商 | Tocris |
| 生物活性 | SelectiveΔ6 desaturase inhibitor (IC50 = 0.2 μMin vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μMin vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 423.55 |
| 分子式 | C27H29N5 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Liet al (2017) Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells. Cell Stem Cell 201. Zhanget al (2010) A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 15 169. PMID: 20086206. Hansen-Petriket al (2002) Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 175 157. PMID: 11741743. Obukowiczet al (1998) Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 287 157. PMID: 9765335. |