| 货号 | 3919/50 |
| 别名 | 4-[5-(4-chlorophenyl)-3-(trifluorom |
| 供应商 | Tocris |
| 生物活性 | Selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 401.79 |
| 分子式 | C16H11ClF3N3O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 170569-86-5 |
| 参考文献 | Roche-Nagleet al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359. PMID: 15213717. Penninget al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347. PMID: 9135032. Gierseet al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810. PMID: 8663121. |