| 货号 | 3315/50 |
| 别名 | 1-(3-Nitrophenyl)-3-(4-pyridinylmet |
| 供应商 | Tocris |
| 生物活性 | Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 411.8 |
| 分子式 | C19H13N5O4.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 152814-89-6 |
| 参考文献 | Bajpaiet al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109. PMID: 16177223. Alvarezet al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616. PMID: 7476886. Kanekoet al (1995) Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell.Signal. 7 527. PMID: 8562314. |