| 货号 | 1559/50 |
| 别名 | 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-py |
| 供应商 | Tocris |
| 生物活性 | Dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 382.93 |
| 分子式 | C23H26N2O.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO with gentle warming |
| CAS号 | 112192-04-8 |
| 参考文献 | Newman-Tancrediet al (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447. PMID: 10431754. Bartoszyket al (1996) Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41. PMID: 8558454. Seyfriedet al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31. PMID: 2565817. |