| 货号 | 2530/50 |
| 别名 | (2S*,3R*)-1-(Phenanthren-2-carbonyl |
| 供应商 | Tocris |
| 生物活性 | Subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for NR2C, NR2D, NR2B and NR2A subunits respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 378.38 |
| 分子式 | C21H18N2O5 |
| 可溶性/溶解性 | Soluble to 50 mM in 2eq. NaOH and to 100 mM in DMSO |
| 参考文献 | Kinarskyet al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066. PMID: 15743930. Morleyet al (2005) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 48 2627. PMID: 15801853. Fenget al (2004) Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 141 508. PMID: 14718249. |