| 货号 | 3197/50 |
| 别名 | (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octa |
| 供应商 | Tocris |
| 生物活性 | TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 234.33 |
| 分子式 | C15H22O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Escaleraet al (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 283 24136. PMID: 18550530. Matsudaet al (2002) Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 12477. Lunde and Kubo (2000) Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 44 1943. PMID: 10858359. |