PF 06260933 dihydrochloride (50 MG)
货号：
5752/50 基本售价：
9894.7 元 规格：
50 mg
产品信息
概述| 货号 | 5752/50 |
| 别名 | 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 369.68 |
| 分子式 | C16H13ClN4.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 20 mM in DMSO |
| 参考文献 | Ammiratiet al (2015) Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 6 1128. PMID: 26617966. |
