| 货号 | 3135/50 |
| 别名 | 6-(Cyclohexylmethoxy)-9H-purin-2-am |
| 供应商 | Tocris |
| 生物活性 | Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 247.3 |
| 分子式 | C12H17N5O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 161058-83-9 |
| 参考文献 | Jensenet al (2005) Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors. Cancer Res. 65 7470. PMID: 16103101. Knockaertet al (2002) Pharmacological inhibitors of cyclin-dependent kinases. TiPS 23 417. PMID: 12237154. Arriset al (2000) Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J.Med.Chem. 43 2797. PMID: 10956187. |