| 货号 | 1240/50 |
| 别名 | 8,8'-[carbonylbis(imino-3,1-phenylen |
| 供应商 | Tocris |
| 生物活性 | A subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i(EC50 ~300 nM). |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 计算分子量 | 1162.86 |
| 分子式 | C35H20N4Na6O21S6 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 104869-31-0 |
| 参考文献 | Sneddonet al (2000) The effect of P2 receptor antagonists and ATPase inhibition on sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 129 1089. PMID: 10725256. Sotoet al (1999) Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38 141. PMID: 10193905. Freissmuthet al (1996) Suramin analogues as subtype-selective G protein inhibitors. Mol.Pharmacol. 49 602. PMID: 8609887. Van Rheeet al (1994) Novel competitive antagonists for P2 purinoceptors. Eur.J.Pharmacol. 268 1. PMID: 7925607. |