MK6-83 (50 MG)
货号：
5547/50 基本售价：
9894.7 元 规格：
50 mg
产品信息
概述| 货号 | 5547/50 |
| 别名 | 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide |
性能| 供应商 | Tocris |
| 生物活性 | TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 336.47 |
| 分子式 | C16H20N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Chenet al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681. PMID: 25119295. |
