| 货号 | 3709/50 |
| 别名 | N1,N4-Di-2,3-butadienyl-1,4-butaned |
| 供应商 | Tocris |
| 生物活性 | Polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 265.23 |
| 分子式 | C12H20N2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 75 mM in DMSO |
| CAS号 | 93565-01-6 |
| 参考文献 | Basuet al (2009) A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 69 7689. PMID: 19773450. Doganet al (1999) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J.Neurochem. 72 765. PMID: 9930751. Beyet al (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J.Med.Chem. 28 1. PMID: 3965702. |