LU AA33810 (50 MG)
货号：
3562/50 基本售价：
9894.7 元 规格：
50 mg
产品信息
概述| 货号 | 3562/50 |
| 别名 | N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 423.62 |
| 分子式 | C19H25N3O2S3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 304008-29-5 |
| 参考文献 | Walkeret al (2009) The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress anxiety. J.Pharmacol.Exp.Ther. 328 900. PMID: 19098165. |
