| 货号 | 2314/50 |
| 别名 | 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 749.29 |
| 分子式 | C41H48N2O9.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 149759-26-2 |
| 参考文献 | Christensenet al (2005) The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 96 316. PMID: 15755315. Tatlisumaket al (2000) Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurol.Sci. 178 107. PMID: 11018702. Krauseet al (1998) LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 244 659. PMID: 9535721. |