| 货号 | 1327/50 |
| 别名 | 11,12,13,13a-Tetrahydro-7-methoxy-9 |
| 供应商 | Tocris |
| 生物活性 | Potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1,α2,α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 341.37 |
| 分子式 | C18H19N3O4 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 130477-52-0 |
| 参考文献 | Atacket al (2006) L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors. Neuropharmacology 51 1023. PMID: 17046030. Suret al (1998) Rat and human hippocampal α5 subunit-containing γ-aminobutyric acidA receptors have α5α3γ2 pharmacological characteristics. Mol.Pharmacol. 54 928. PMID: 9804628. Quirket al (1996) [3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit. Neuropharmacology 35 1331. PMID: 9014149. |