| 货号 | 3834/50 |
| 别名 | (±)-2-(1H-benzimidazol-2-ylthio)prop |
| 供应商 | Tocris |
| 生物活性 | Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μMin vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 419.3 |
| 分子式 | C17H15BrN4O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 330676-02-3 |
| 参考文献 | Kumaret al (2009) Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 284 14760. PMID: 19336406. Stessinet al (2006) Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 281 17253. PMID: 16627466. Hesset al (2005) The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Develop.Cell 9249. |