| 货号 | 4715/50 |
| 别名 | 4-[(3-Phenoxyphenyl)methyl]-1-piper |
| 供应商 | Tocris |
| 生物活性 | Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 433.46 |
| 分子式 | C24H23N3O5 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Wiseet al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369. PMID: 22860205. Wiskerkeet al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407. PMID: 22860210. Longet al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270. PMID: 19918051. |