| 货号 | 5081/50 |
| 别名 | 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methox |
| 供应商 | Tocris |
| 生物活性 | Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro(EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 350.33 |
| 分子式 | C18H17F3N2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Chirutaet al (2013) Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 21 2733. PMID: 23582448. Prioret al (2013) The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimers disease mice. Alzheimers.Res.Ther. 5 25. PMID: 23673233. Chenet al (2011) A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 6 e27865. PMID: 22194796. |