| 货号 | 1219/50 |
| 别名 | 7-Chloro-3-methyl-3,4-dihydro-2H-1, |
| 供应商 | Tocris |
| 生物活性 | Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (Cat. No. 0713). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 232.68 |
| 分子式 | C8H9ClN2O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 22503-72-6 |
| 参考文献 | Impagnatielloet al (1997) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proc.Natl.Acad.Sci.U.S.A. 94 7053. PMID: 9192690. Thompsonet al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proc.Natl.Acad.Sci.U.S.A. 92 7667. PMID: 7644474. Zivkovicet al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J.Pharmacol.Exp.Ther. 272 300. PMID: 7815345. |