| 货号 | 5636/50 |
| 别名 | 4-[4-[[5-(2-Fluorophenyl)-2-furanyl |
| 供应商 | Tocris |
| 生物活性 | β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 466.46 |
| 分子式 | C28H19FN2O4< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Hiroseet al (2008) GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem.Biophys.Res.Comm. 374 507. PMID: 18656449. Nakajimaet al (2008) A novel small-molecule inhibitor of NF-κB signaling. Biochem.Biophys.Res.Comm. 368 1007. PMID: 18275844. |