| 货号 | 1263/50 |
| 别名 | 4-[4-[4-(Aminoiminomethyl)phenyl]-1 |
| 供应商 | Tocris |
| 生物活性 | A potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 454.83 |
| 分子式 | C18H27N5O2.3HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 201304-22-5 |
| 参考文献 | Matsunoet al (1999) Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 127 1129. PMID: 10455258. Matsunoet al (1997) GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 122 1099. PMID: 9480031. Eldredet al (1994) Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 37 3882. PMID: 7966149. |