| 货号 | 3889/50 |
| 别名 | 2,3,4,5-Tetra(4-pyridyl)thiophene |
| 供应商 | Tocris |
| 生物活性 | GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 392.48 |
| 分子式 | C24H16N4S |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 64048-12-0 |
| 参考文献 | Beauchampet al (2009) GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 284 9074. PMID: 19189974. Jooet al (2009) GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 4 7608. PMID: 19859563. Lauthet al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 104 8455. PMID: 17494766. |