| 货号 | 5180/50 |
| 别名 | Ethyl 3-amino-4-(cyclohexylamino)benzoate |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 262.35 |
| 分子式 | C15H22N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Skoutaet al (2014) Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551. PMID: 24592866. Louandreet al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int.J.Cancer 133 1732. PMID: 23505071. Dixonet al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060. PMID: 22632970. |