| 货号 | 1430/50 |
| 别名 | 5-Bromo-2-(4-fluorophenyl)-3-[4-(me |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of cyclooxygenase-2 (IC50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 411.3 |
| 分子式 | C17H12BrFO2S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 88149-94-4 |
| 参考文献 | Rossoniet al (2002) Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit. Br.J.Pharmacol. 135 1540. PMID: 11906968. Gierseet al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479. PMID: 7832763. Ganset al (1990) Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J.Pharmacol.Exp.Ther. 254 180. PMID: 2366180. |