| 货号 | 5459/50 |
| 别名 | Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzen |
| 供应商 | Tocris |
| 生物活性 | Naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 322.4 |
| 分子式 | C18H26O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Palumbo-Zerret al (2015) Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 21 150. PMID: 25581517. Zhanet al (2008) Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 4 548. PMID: 18690216. |