| 货号 | 2227/50 |
| 别名 | 2,2-Dimethyl-N-(2,4,6-trimethoxyphe |
| 供应商 | Tocris |
| 生物活性 | Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 393.57 |
| 分子式 | C23H39NO4 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 114289-47-3 |
| 参考文献 | Drecktrahet al (2003) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell 143549. Krauseet al (1993) In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 34 279. PMID: 8429262. Sliskovic and White (1991) Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS. 12194. |