| 货号 | 2095/50 |
| 别名 | N-Cyclohexyl-N'-tricyclo[3.3.1.13,7] |
| 供应商 | Tocris |
| 生物活性 | Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 381.98 |
| 分子式 | C21H35N3O.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 57568-80-6 |
| 参考文献 | Kovalevet al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867. PMID: 14757705. Cuiet al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122. PMID: 12746230. Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894. PMID: 9641474. |