| 货号 | 0915/50 |
| 别名 | N-Cyclohexyl-N-methyl-4-(1,2-dihydr |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC50 values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM); antithrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 342.44 |
| 分子式 | C20H26N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 68550-75-4 |
| 参考文献 | Sudoet al (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 59 347. PMID: 10644042. Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29185. Hidakiet al (1979) Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 211 26. PMID: 226672. |