VU 0483605 (50 MG)
货号：
5377/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5377/50 |
| 别名 | 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator at mGlu1(EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 446.67 |
| 分子式 | C20H10Cl3N3< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Choet al (2014) Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. ACS Chem.Biol. 9 2334. PMID: 25137254. |
