SR 9238 ( )
货号：
5854/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5854/50 |
| 别名 | Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 595.73 |
| 分子式 | C31H33NO7S2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Griffettet al (2013) A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem.Biol. 8 559. PMID: 23237488. |
