| 货号 | 1267/50 |
| 别名 | 1-(4-Methylphenyl)-2-(4,5,6,7-tetra |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). Cyclic analog available (Cat. No. 3843). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 367.3 |
| 分子式 | C16H18N2OS.HBr |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 63208-82-2 |
| 参考文献 | Abdelalim and Tooyama (2012) The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells. Biochem.Biophys.Res.Comm. 420 605. PMID: 22445757. Hoaglandet al (2005) The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor. J.Pharmacol.Exp.Ther. 314 603. PMID: 15843497. Culmseeet al (2001) A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β-peptide. J.Neurochem. 77 220. PMID: 11279278. Komarova and Gudkov (2000) Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry 65 41. PMID: 10702639. Komarovet al (1999) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285 1733. PMID: 10481009. |