| 货号 | 2929/50 |
| 别名 | 2-[2,6-Difluoro-4-[[2-[(phenylsulfo |
| 供应商 | Tocris |
| 生物活性 | Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 402.44 |
| 分子式 | C16H16F2N2O4S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 141286-78-4 |
| 参考文献 | Sekiguchiet al (2002) A desensitization-selective potentiator of AMPA-type glutamate receptors. Br.J.Pharmacol. 136 1033. PMID: 12145103. Sekiguchiet al (2001) The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport 122974. Sekiguchiet al (1997) A novel allosteric potentiator of AMPA receptors: 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide. J.Neurosci. 17 5760. PMID: 9221774. |