| 货号 | 4655/50 |
| 别名 | 2-Hydroxy-4-[[2-[[(4-methylphenyl)s |
| 供应商 | Tocris |
| 生物活性 | Selectively inhibits STAT3 DNA-binding activity in vitro(IC50 values are 86, 160, and >300μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 365.36 |
| 分子式 | C16H15NO7S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Linet al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961. PMID: 19137011. Siddiqueeet al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391. PMID: 17463090. |