| 货号 | 3190/50 |
| 别名 | Z-5-(4-Hydroxybenzylidene)-2-imino- |
| 供应商 | Tocris |
| 生物活性 | Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 220.25 |
| 分子式 | C10H8N2O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Garneret al (2009) Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 5 129. PMID: 19219009. Dupreet al (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 4 119. PMID: 18176557. Stivers (2008) Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 4 86. PMID: 18202674. |