| 货号 | 4651/50 |
| 别名 | Trispiro[3H-indole-3,2'-[1,3]dioxane |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 394.38 |
| 分子式 | C21H18N2O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Shultzet al (2012) [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J.Med.Chem. 55 1127. PMID: 22260203. Waaleret al (2011) Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 71 197. PMID: 21199802. |