| 货号 | 2677/50 |
| 别名 | 7-Amino-4-chloro-3-methoxy-1H-2-ben |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Prevents recovery of Aβ40 and Aβ42 from HEK293 cell overexpressing wild-type or Swedish-mutated βAPP (IC50 ~ 30 μM) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α-secretase, the proteosome or GSK3β. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 225.63 |
| 分子式 | C10H8ClNO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 62252-26-0 |
| 参考文献 | Hellstromet al (2007) DII4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445 776. PMID: 17259973. Petitet al (2003) JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J.Neurosci.Res. 74 370. PMID: 14598313. Petitet al (2001) New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nat.Cell.Biol. 3 507. PMID: 11331880. |