| 货号 | 3663/50 |
| 别名 | 1,1-Dimethylethyl-N-[(4-chloropheny |
| 供应商 | Tocris |
| 生物活性 | Selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 396.89 |
| 分子式 | C18H21ClN2O4S |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Kojetinet al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131. PMID: 21043485. Menget al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 1213629. |