| 货号 | 2496/50 |
| 别名 | 1,5,7,8-Tetrahydro-2-methyl-4H-thio |
| 供应商 | Tocris |
| 生物活性 | Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivoandin vitro. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 182.24 |
| 分子式 | C8H10N2OS |
| 可溶性/溶解性 | Soluble to 40 mM in water |
| CAS号 | 284028-90-6 |
| 参考文献 | Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421. PMID: 15864271. Nakajimaet al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472. PMID: 15466246. |