| 货号 | 3360/50 |
| 别名 | 5,6-Bis(phenylamino)-1H-isoindole-1 |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of the epidermal growth factor receptor (EGFR) (IC50 = 0.3 μMin vitro). Also inhibits and reverses the formation of Aβ42 fibers associated with Alzheimer's disease. Eliminates calcium influx potential when coincubated with amyloid β-peptide (1-42) (Cat.No. 1428); reduces neurotoxicity by blocking Ca2+ influx into neuronal cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 329.35 |
| 分子式 | C20H15N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 145915-58-8 |
| 参考文献 | Wanget al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci. 105 7159. PMID: 18480256. Blanchardet al (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc.Natl.Acad.Sci. 101 14326. PMID: 15388848. Buchdungeret al (1994) 4,5-dianilinophthalimide: a protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc.Natl.Acad.Sci. 91 2334. PMID: 8134396. |