| 货号 | 2639/50 |
| 别名 | α-Phenyl-N-[2,2,2-trichloro-1-[[[(4- |
| 供应商 | Tocris |
| 生物活性 | Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 555.84 |
| 分子式 | C23H18Cl3FN4O3S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 905973-89-9 |
| 参考文献 | Alao and Sunnerhagen (2009) The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat.Oncol. 10 4. PMID: 19903334. Bhattacharyaet al (2009) Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal. 21 509. PMID: 19136059. Crescenziet al (2008) Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin.Cancer Res. 14 1877. PMID: 18347191. Cruet-Hennequartet al (2008) Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase η-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair 7 582. PMID: 18289945. Goldsteinet al (2008) Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: Contribution of DNA replication, transcription inhibition and Chk/p53 signaling. Toxicol.Appl.Pharmacol. 229 20. PMID: 18289623. Wonet al (2008) Retraction: small molecule-based reversible reprogramming of cellular lifespan. Nat.Chem.Biol. 4 431. PMID: 18560433. |