CBR 5884 (50 MG)
货号：
5836/50 基本售价：
9359.3 元 规格：
50 mg
产品信息
概述| 货号 | 5836/50 |
| 别名 | Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate |
性能| 供应商 | Tocris |
| 生物活性 | 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 336.39 |
| 分子式 | C14H12N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Mullarkyet al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778. PMID: 26831078. |
