UNC3230
货号：
16401-50mg 基本售价：
9310.0 元 规格：
50 mg
产品信息
概述| 货号 | 16401-50mg |
| 描述 | Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG).1 Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2.1 UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM).1 It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases.1 At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wright, B.D.,Loo, L.,Street, S.E., et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82(4), 836-847 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 344.1 |
| 分子式 | C17H20N4O2S |
| CAS号 | 1031602-63-7 |
| 稳定性 | ≥ 2 years |
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