| 货号 | 11612-10mg |
| 描述 | Analogs of prostaglandin F2α(PGF2α), which act primarily at the FP receptor, have been approved for the treatment of glaucoma.1,2,3,4 Tafluprost (free acid) (Item No. 10005439) is a PGF2α analog which acts as a potent FP receptor agonist (Ki = 0.4 nM).5 Tafluprost ethyl ester is a form of tafluprost which may have increased lipid solubility compared to the free acid. In addition, the ethyl ester form may demonstrate improved uptake into tissues and thus lower the effective concentration. |
| 别名 | AFP 175; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Parrish, R.K.,Palmberg, P., and Sheu, W.P. A comparison of latanoprost, bimatoprost, and travoprost in patients with elevated intraocular pressure: A 12-week, randomized, masked-evaluator multicenter study. American Journal of Ophthalmology 135, 688-703 (2003). 2.Ota, T.,Murata, H.,Sugimoto, E.i., et al. Prostaglandin analogues and mouse intraocular pressure: Effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation. Investigative Ophthalmology & Visual Science 46(6), 2006-2011 (2005). 3.Hommer, A., and Kimmich, F. Switching patients from preserved prostaglandin-analog monotherapy to preservative-free tafluprost. Clin.Ophthalmol. 5, 623-631 (2011). 4.Januleviciene, I.,Derkac, I.,Grybauskiene, L., et al. Effects of preservative-free tafluprost on tear film osmolarity, tolerability, and intraocular pressure in previously treated patients with open-angle glaucoma. Clin.Ophthalmol. 6, 103-109 (2012). 5.Takagi, Y.,Nakajima, T.,Shimazaki, A., et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Experimental Eye Research 78, 767-776 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 438.5 |
| 分子式 | C24H32F2O5 |
| CAS号 | 209860-89-9 |
| 稳定性 | ≥ 1 year |
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